This study intends to describe growth and endocrine disorders secondary to chemotherapy among long-term survivors of pediatric acute leukemia. Sixteen patients including 14 ALL and 2 AML entered the study. Four were females and 12 were males with the mean age of 17.38 ± 3.81 years. Following the completion of their therapy, the mean follow up period of the patients was 62.43 ± 41.11 months. Somatic growth, sexual maturation, hypothalamic- pituitary-thyroid axis and hypothalamic-pituitary-gonadal axis were evaluated in all the patients. Two out of 16 had pathologic short stature (12.5%) and 3 patients had enuchoid status (18.75%) with antrophometric measurements. Eleven patients had normal thyroid gland dimensions and homogeneous thyroid tissue on ultrasonographic examination. One patient had Ia and another four patients had Ib diffuse goitre according to WHO criteria. Two out of 16 patients were diagnosed as subclinic primary hypothyroidism (12.5%), and three of them were diagnosed as subclinic central hypothyroidism (18.75%) according to TRH testing. Three patients were subclinic subtle central hypothyroidism. Thyroid auto-antibodies were in normal range in all patients. Eight patients (66.6%) out of 12 male subjects revealed impaired HHG axis. Hypergonadotropic hypogonadism (Leydig and Sertoli dysfunction) were observed in five of them and isolated Sertoli dysfunction was detected in three of them. Azoospermia was encountered in all patients with isolated Sertoli dysfunction. Testicular biopsy was obtained from only one of them and atrophic testicular tissue was detected. Female patients show normal pubertal development and gonadal functions. CONCLUSION: Subclinic subtle primary and subclinic central hypothyroidism were found in 31.2%, impaired Sertoli and Leydig with Sertoli cell function in 66.66% of long-term survivors pediatric acute leukemia and testicular tissue was more sensitive to adverse effects of chemotherapy than ovarian tissue.addictive behavior
adolescent compulsive gambling
gambling click here to see if you are a compulsive online trader
addictive behavior
adolescent compulsive gambling
gambling information click here to see if you are a compulsive online trader
addictive behavior
adolescent compulsive gambling
http://www.800gambler.org/ click here to see if you are a compulsive online trader
addictive behavior
adolescent compulsive gambling
http://www.800gambler.org/ click here to see if you are a compulsive online trader
buy biaxin without prescription
buy biaxin online
cheap biaxin buy biaxin
buy abortion pill online
cytotec abortion pill buy online
abortion pills buy abortion pill online
buy abortion pill online
cytotec abortion pill buy online
abortion pill buy abortion pill online
abortion pill prescription
abortion pill buy online
abortion pill cytotec abortion
mail order viagra without prescription
buy viagra online a href
alternative to viagra viagra for sale without a prescription
mail order viagra without prescription
buy viagra online a href
female viagra alternative viagra for sale without a prescription
mail order viagra without prescription
buy viagra online a href
female viagra alternative viagra for sale without a prescription
kamagra without prescription
photos kamagra
kamagra herbal kamagra alternative
kamagra without prescription
photos kamagra
kamagra herbal kamagra alternative
herbal kamagra jelly alternative
kamagra jelly pharmacy
kamagra jelly free kamagra jelly
amoxicillin uk
mail order amoxil
generic amoxil amoxil prescription buy
natural synthroid
synthroid prescription buy
synthroid where to buy thyroxine online
natural synthroid
synthroid prescription buy
natural synthroid where to buy thyroxine online
female herbal laxative
order laxative online
laxative get bisacodyl
female herbal laxative
order laxative online
laxative get bisacodyl
ampicillin prescription buy
buy principen in great britain
ampicillin photos ampicillin
ampicillin prescription buy
buy principen in great britain
ampicillin photos ampicillin
ampicillin prescription buy
buy principen in great britain
get ampicillin photos ampicillin
ampicillin prescription buy
buy principen in great britain
get ampicillin photos ampicillin
ampicillin prescription buy
buy principen in great britain
get ampicillin photos ampicillin
purchase cipro online
get ciprofloxacin
ciprofloxacin cheap ciprofloxacin
purchase cipro online
get ciprofloxacin
ciprofloxacin cheap ciprofloxacin
purchase cipro online
get ciprofloxacin
order cipro cheap ciprofloxacin
cleocin online shop in uk
get clindamycin avoid prescription
clindamycin cleocin online
cleocin online shop in uk
get clindamycin avoid prescription
clindamycin cleocin online
order dexone
female herbal dexone
dexamethasone alternative to dexamethasone
order dexone
female herbal dexone
dexamethasone alternative to dexamethasone
order dexone
female herbal dexone
dexamethasone alternative to dexamethasone
natural duricef
natural Cefadroxil
cefadroxil female free sample Cefadroxil
natural duricef
natural Cefadroxil
cefadroxil female free sample Cefadroxil
order vantin
natural vantin
cefpodoxime vantin prescription buy
order vantin
natural vantin
cefpodoxime vantin prescription buy
order vantin
natural vantin
cefpodoxime vantin prescription buy
generic ceftin
buy ceftin online a href
cefuroxime buy ceftin online safe
generic ceftin
buy ceftin online a href
cefuroxime buy ceftin online safe
abortion pill buy online
where can i buy abortion pills
abortion pill order abortion pill
abortion pill buy online
where can i buy abortion pills
abortion pill order abortion pill
abortion pill buy online
where can i buy abortion pills
abortion pill order abortion pill
keflex without prescription
buy keflex online
cephalexin get keflex online
keflex without prescription
buy keflex online
cephalexin get keflex online
keflex without prescription
buy keflex online
cephalexin get keflex online
keflex without prescription
buy keflex online
cephalexin get keflex online
keflex without prescription
buy keflex online
buy cephalexin get keflex online
how does chloromycetin work
how to use chloramphenicol
chloramphenicol order chloromycetin online
how does chloromycetin work
how to use chloramphenicol
chloramphenicol order chloromycetin online
abortion pills
where can you buy the abortion pill
abortion pill pill for abortion online
buy augmentin online
how to use augmentin
augmentin female free sample augmentin